Asymmetric Syntheses of ( E )-δ-Hydroxymethyl- anti -homoallylic Alcohols via Highly Enantio- and Stereoselective Aldehyde Allylation with α-Borylmethyl-( E )-crotylboronate.

Highly stereo- and enantioselective synthesis of ( E )-δ-hydroxymethyl- anti -homoallylic alcohols is reported. Under the developed conditions, reactions between aldehydes and chiral nonracemic α-borylmethyl-( E )-crotylboronate upon oxidative workup gave δ-hydroxymethyl- anti -homoallylic alcohols with high E -selectivities and enantioselectivities.