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Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia.
- Source :
-
Scientific reports [Sci Rep] 2021 Sep 23; Vol. 11 (1), pp. 18929. Date of Electronic Publication: 2021 Sep 23. - Publication Year :
- 2021
-
Abstract
- Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI-citrulline, intestinal fatty acid-binding protein (I-FABP), and D-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients-50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0-26.0) vs. 23.3 μmol/L (18.3-29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58-0.78). No statistical difference was found in plasma I-FABP and plasma D-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and D-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.<br /> (© 2021. The Author(s).)
- Subjects :
- Abdomen, Acute blood
Abdomen, Acute etiology
Adult
Aged
Biomarkers
Citrulline blood
Cross-Sectional Studies
Fatty Acid-Binding Proteins blood
Female
Humans
Lactic Acid blood
Male
Mesenteric Ischemia blood
Mesenteric Ischemia complications
Middle Aged
Tomography, X-Ray Computed
Abdomen, Acute diagnosis
Early Diagnosis
Mesenteric Ischemia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34556697
- Full Text :
- https://doi.org/10.1038/s41598-021-98012-w