Cliniatines A-C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase.

Authors :: Hirasawa Y
Tanaka T
Hirasawa S
Wong CP
Uchiyama N
Kaneda T
Goda Y
Morita H
Source :: Journal of natural medicines [J Nat Med] 2022 Jan; Vol. 76 (1), pp. 171-177. Date of Electronic Publication: 2021 Sep 22.
Publication Year :: 2022
Abstract: Cliniatines A-C (1-3), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated from Clivia miniata (Lindl.) Bosse. The structures and absolute configurations of 1-3 were elucidated based on spectroscopic data and chemical correlation. Cliniatines A-C showed moderate inhibitory activity against acetylcholinesterase.<br /> (© 2021. The Japanese Society of Pharmacognosy.)

Subjects :: Acetylcholinesterase
Cholinesterase Inhibitors pharmacology
Plant Extracts
Amaryllidaceae
Amaryllidaceae Alkaloids pharmacology

Full Text Access

Tools