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Rituximab Treatment of Hairy Cell Leukemia in a Patient with Mycobacterium kansasii Infection: A Case Report.
- Source :
-
Oncology research and treatment [Oncol Res Treat] 2021; Vol. 44 (11), pp. 637-640. Date of Electronic Publication: 2021 Sep 21. - Publication Year :
- 2021
-
Abstract
- Introduction: Infectious complications represent a major cause of morbidity and mortality in hairy cell leukemia (HCL) patients. Due to the immunosuppressive nature of the disease, these patients are frequently affected by opportunistic infections and rare pathogens. Furthermore, cytotoxic chemotherapy might lead to poor or even fatal outcomes in the setting of an active infection.<br />Case Presentation: We report the case of a 62-year-old HCL patient who presented with recurrent fever episodes, pancytopenia, and mediastinal lymphadenopathy. A treatment decision against purine analogs and for rituximab mono was made as lymph node tissue revealed disseminated Mycobacterium kansasii infection. Together with specific antimycobacterial treatment, rituximab mono led to complete hematologic remission after 6 months without aggravating the accompanying infection.<br />Conclusion: Here, we demonstrate successful treatment of HCL with rituximab in a patient with concomitant disseminated M. kansasii infection.<br /> (© 2021 S. Karger AG, Basel.)
- Subjects :
- Humans
Middle Aged
Mycobacterium kansasii
Leukemia, Hairy Cell complications
Leukemia, Hairy Cell drug therapy
Mycobacterium Infections, Nontuberculous diagnosis
Mycobacterium Infections, Nontuberculous drug therapy
Opportunistic Infections diagnosis
Opportunistic Infections drug therapy
Rituximab therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2296-5262
- Volume :
- 44
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Oncology research and treatment
- Publication Type :
- Report
- Accession number :
- 34547751
- Full Text :
- https://doi.org/10.1159/000519301