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Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.

Authors :
Deng MY
Sturm D
Pfaff E
Sill M
Stichel D
Balasubramanian GP
Tippelt S
Kramm C
Donson AM
Green AL
Jones C
Schittenhelm J
Ebinger M
Schuhmann MU
Jones BC
van Tilburg CM
Wittmann A
Golanov A
Ryzhova M
Ecker J
Milde T
Witt O
Sahm F
Reuss D
Sumerauer D
Zamecnik J
Korshunov A
von Deimling A
Pfister SM
Jones DTW
Source :
Nature communications [Nat Commun] 2021 Sep 20; Vol. 12 (1), pp. 5530. Date of Electronic Publication: 2021 Sep 20.
Publication Year :
2021

Abstract

Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (nā€‰=ā€‰23) and ALL (nā€‰=ā€‰9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.<br /> (© 2021. The Author(s).)

Details

Language :
English
ISSN :
2041-1723
Volume :
12
Issue :
1
Database :
MEDLINE
Journal :
Nature communications
Publication Type :
Academic Journal
Accession number :
34545083
Full Text :
https://doi.org/10.1038/s41467-021-25708-y