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Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
- Source :
-
Nature communications [Nat Commun] 2021 Sep 20; Vol. 12 (1), pp. 5530. Date of Electronic Publication: 2021 Sep 20. - Publication Year :
- 2021
-
Abstract
- Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (nā=ā23) and ALL (nā=ā9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.<br /> (© 2021. The Author(s).)
- Subjects :
- Adolescent
Adult
Child
Chromosome Deletion
Cluster Analysis
DNA Methylation genetics
Female
Gene Expression Regulation, Neoplastic
Gene Rearrangement genetics
Genome, Human
Glioma pathology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Radiation
Receptor, Platelet-Derived Growth Factor alpha metabolism
Transcription, Genetic
Young Adult
Cyclin-Dependent Kinase Inhibitor p15 metabolism
Cyclin-Dependent Kinase Inhibitor p16 metabolism
Gene Amplification
Glioma genetics
Neoplasm Recurrence, Local pathology
Receptor, Platelet-Derived Growth Factor alpha genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 34545083
- Full Text :
- https://doi.org/10.1038/s41467-021-25708-y