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Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Sep 20; Vol. 105 (5), pp. 1227-1229. Date of Electronic Publication: 2021 Sep 20. - Publication Year :
- 2021
-
Abstract
- To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 105
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 34544043
- Full Text :
- https://doi.org/10.4269/ajtmh.21-0542