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Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

Authors :
Neuman BW
Brashear WA
Brun M
Chaki SP
Fischer RSB
Guidry SJ
Hill JE
Hillhouse AE
Johnson CD
Kahl-McDonagh MM
Metz RP
Rice-Ficht AC
Shuford JA
Skaggs TA
Stull MA
Threadgill DW
Akpalu Y
Zuelke K
Source :
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Sep 20; Vol. 105 (5), pp. 1227-1229. Date of Electronic Publication: 2021 Sep 20.
Publication Year :
2021

Abstract

To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.

Details

Language :
English
ISSN :
1476-1645
Volume :
105
Issue :
5
Database :
MEDLINE
Journal :
The American journal of tropical medicine and hygiene
Publication Type :
Academic Journal
Accession number :
34544043
Full Text :
https://doi.org/10.4269/ajtmh.21-0542