Back to Search
Start Over
Infection and autoinflammation in inborn errors of immunity: brothers in arms.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2021 Oct; Vol. 72, pp. 331-339. Date of Electronic Publication: 2021 Sep 17. - Publication Year :
- 2021
-
Abstract
- The binary view of inborn errors of immunity classified as either autoinflammatory conditions or primary immunodeficiency in the strict sense, that is, increased susceptibility to infection is challenged by the description of recent inborn errors of immunity (IEI) triggers leading to activation and disruption of cell death pathways, play a major part in the pathophysiology of infection and autoinflammation. In addition, molecules with a double role in the extracellular versus intracellular milieu add to the complexity. In all, in-depth study of human inborn errors of immunity will continue to instruct us on fundamental immunology and lead to novel therapeutic targets and approaches that can be used in other monogenic and polygenic/complex immune disorders.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Alleles
Animals
Autoantibodies immunology
Biomarkers
Endoplasmic Reticulum Stress
Genotype
Humans
Infections diagnosis
Infections metabolism
Inflammation diagnosis
Inflammation metabolism
Interferon Type I immunology
Interferon Type I metabolism
Mutation
Organ Specificity genetics
Organ Specificity immunology
Phenotype
Signal Transduction
Autoimmunity genetics
Genetic Predisposition to Disease
Genetic Variation
Immunity genetics
Infections etiology
Inflammation etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0372
- Volume :
- 72
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34543865
- Full Text :
- https://doi.org/10.1016/j.coi.2021.08.004