Curcumin improves angiogenesis in the heart of aged rats: Involvement of TSP1/NF-κB/VEGF-A signaling.

Authors :: Ghorbanzadeh V
Pourheydar B
Dariushnejad H
Ghalibafsabbaghi A
Chodari L
Source :: Microvascular research [Microvasc Res] 2022 Jan; Vol. 139, pp. 104258. Date of Electronic Publication: 2021 Sep 17.
Publication Year :: 2022
Abstract: Background: Cardiac aging is an irreversible process that is determined by a number of slowly deleterious changes in morphological and physiological properties of the heart. We investigated the effects of curcumin on cardiac angiogenesis, in old male rats.<br />Materials and Methods: Rats randomly divided into young, age (rats of 26-28 months of age) and curcumin-age (rats of 26-28 months of age treatment with curcumin 50mg/kg). Finally, the expression of VEGF, NF-κB, and TSP-1 were assessed by ELISA in cardiac tissue. Also, angiogenesis was determined by immunostaining for PECAM-1/CD31 and apoptosis was evaluated by TUNEL.<br />Results: After 2 months, curcumin-age had significantly higher cardiac VEGF-A and NF-κB and lower cardiac TSP-1 expression levels in comparison with age and young. A significant increase in levels of NF-κB and TSP-1 were observed in the age group.<br />Conclusion: Results suggest that curcumin through regulation of cardiogenic mediators and improving cardiac angiogenesis can promote heart performance in the senescent rats.<br /> (Copyright © 2021. Published by Elsevier Inc.)

Subjects :: Age Factors
Animals
Apoptosis drug effects
Coronary Vessels metabolism
Coronary Vessels pathology
Male
Myocardium metabolism
Myocardium pathology
Rats, Wistar
Signal Transduction
Rats
Angiogenesis Inducing Agents pharmacology
Coronary Vessels drug effects
Curcumin pharmacology
NF-kappa B metabolism
Neovascularization, Physiologic drug effects
Thrombospondin 1 metabolism
Vascular Endothelial Growth Factor A metabolism

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