Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis.

Authors :: Sun KY
Wu Y
Xu J
Xiong W
Xu W
Li J
Sun Z
Lv Z
Wu XS
Jiang Q
Cai HL
Shi D
Source :: Bioactive materials [Bioact Mater] 2021 Jul 01; Vol. 8, pp. 435-448. Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2022).
Publication Year :: 2021
Abstract: Joint replacement surgery is one of the orthopedic surgeries with high successful rates; however, wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the implant. The implant-derived particulate debris such as ultrahigh molecular weight polyethylene (UHMWPE) can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species (ROS). ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of osteolysis. In this work, we develop the few-layered Nb <subscript>2</subscript> C (FNC) as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS adsorption. Moreover, local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial model. In sum, our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.<br /> (© 2021 The Authors.)