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Preparation of magnetic yolk-shell structured metal-organic framework material and its application in pharmacokinetics study of alkaloids.
- Source :
-
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2021 Nov; Vol. 413 (28), pp. 6987-6999. Date of Electronic Publication: 2021 Sep 17. - Publication Year :
- 2021
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Abstract
- In this study, a magnetic yolk-shell structured metal-organic framework material (Fe <subscript>3</subscript> O <subscript>4</subscript> @YS-UiO-66-NH <subscript>2</subscript> ) is prepared by the directional etching of Co <superscript>2+</superscript> /peroxymonosulfate and in situ magnetization. The characteristic properties of the material were investigated by using field emission scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometer, Brunauer-Emmett-Teller, and contact angle test. The Fe <subscript>3</subscript> O <subscript>4</subscript> @YS-UiO-66-NH <subscript>2</subscript> shows the advantages of large surface area, good magnetic property, and satisfactory stability, as well as giving high affinity to alkaloids (ALs) via hydrophilic interaction, hydrogen bonding, and π-π interaction. The results of static adsorption experiment indicate that the Fe <subscript>3</subscript> O <subscript>4</subscript> @YS-UiO-66-NH <subscript>2</subscript> possesses high adsorption capacity towards ALs and the adsorption behaviors are fitted with Langmuir adsorption isotherm model. Furthermore, a magnetic solid-phase extraction using Fe <subscript>3</subscript> O <subscript>4</subscript> @YS-UiO-66-NH <subscript>2</subscript> and HPLC method was developed for the analysis of ALs in spiked samples with the recovery of 89.6-100.8%. In addition, the proposed method was successfully applied in the pharmacokinetics study of berberine, coptisine, and palmatine in the rat. In short, the developed method might be used for high-efficient recognition and determination of ALs in plasma sample, which would also provide a new way to fabricate magnetic functionalized metal-organic framework in separation science.<br /> (© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Alkaloids blood
Animals
Female
Limit of Detection
Male
Microscopy, Electron, Scanning methods
Microscopy, Electron, Transmission methods
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Spectrum Analysis methods
Zirconium chemistry
Alkaloids pharmacokinetics
Magnetics
Metal-Organic Frameworks chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1618-2650
- Volume :
- 413
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- Analytical and bioanalytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34535814
- Full Text :
- https://doi.org/10.1007/s00216-021-03656-2