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Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species.
- Source :
-
PLoS pathogens [PLoS Pathog] 2021 Sep 16; Vol. 17 (9), pp. e1009880. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Staphylococcus aureus is a human commensal organism and opportunist pathogen, causing potentially fatal disease. The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases S. aureus pathogenicity, a process termed augmentation. Augmentation is associated with macrophage interaction but by a hitherto unknown mechanism. Here, we demonstrate a breadth of cross-kingdom microorganisms can augment S. aureus disease and that pathogenesis of Enterococcus faecalis can also be augmented. Co-administration of augmenting material also forms an efficacious vaccine model for S. aureus. In vitro, augmenting material protects S. aureus directly from reactive oxygen species (ROS), which correlates with in vivo studies where augmentation restores full virulence to the ROS-susceptible, attenuated mutant katA ahpC. At the cellular level, augmentation increases bacterial survival within macrophages via amelioration of ROS, leading to proliferation and escape. We have defined the molecular basis for augmentation that represents an important aspect of the initiation of infection.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Animals
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Reactive Oxygen Species metabolism
Sepsis immunology
Sepsis microbiology
Staphylococcal Infections immunology
Zebrafish
Host-Pathogen Interactions immunology
Macrophages immunology
Staphylococcal Infections microbiology
Staphylococcus aureus immunology
Symbiosis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1553-7374
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PLoS pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 34529737
- Full Text :
- https://doi.org/10.1371/journal.ppat.1009880