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Intensity modulated radiotherapy in anal canal squamous cell carcinoma: Implementation and outcomes.
- Source :
-
Journal of cancer research and therapeutics [J Cancer Res Ther] 2021 Jul-Sep; Vol. 17 (4), pp. 975-981. - Publication Year :
- 2021
-
Abstract
- Objective: Concurrent chemoradiotherapy (CCRT) is the standard curative treatment option for nonmetastatic anal squamous cell carcinoma (SCC). Intensity modulated radiotherapy (IMRT) can reduce doses delivered to bowel and skin and reduce toxicities associated with conventional fields. Here, we present our institutional data on dosimetry, toxicity, and clinical outcomes with IMRT for anal cancer.<br />Materials and Methods: We analyzed 23 patients of anal SCC treated with curative-intent CCRT/radiation therapy alone, utilizing IMRT, between August 2011 and December 2016. The standard prescription dose was 54 Gy/27Fr/5.5 weeks, delivered in two phases, and concurrent chemotherapy with 5-fluorouracil and mitomycin-C. Acute and late toxicities and dosimetric data were compiled and analyzed.<br />Results: The median age was 65 years. Fourteen (60.7%) patients had Stage IIIC disease. Eighteen patients received concurrent chemotherapy. No patient had any treatment breaks. Grade 3 acute perianal dermatitis was recorded in 11 (47.8%) patients. Proctitis, diarrhea, and cystitis were limited to Grade 1 in 73.9%, 47.8%, and 8.6% patients, respectively. The only late Grade 2+ toxicities were gastrointestinal toxicities in 4 (17.4%) patients. Twenty (87%) patients had complete response at 6 months. The 3-year local control, nodal control, and distant metastases-free survival were 85.9%, 86.6%, 84.7%, respectively, with 3-year disease-free survival and overall survival of 63.4% and 81%, respectively.<br />Conclusion: In this report on IMRT in anal cancer from India, treatment was well tolerated with lower acute toxicity than reported in other prospective studies. Long-term results are at par with other published studies.<br />Competing Interests: None
- Subjects :
- Aged
Anus Neoplasms pathology
Anus Neoplasms therapy
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Retrospective Studies
Survival Rate
Treatment Outcome
Anus Neoplasms mortality
Carcinoma, Squamous Cell mortality
Chemoradiotherapy mortality
Radiotherapy Planning, Computer-Assisted methods
Radiotherapy, Intensity-Modulated mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4138
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 34528551
- Full Text :
- https://doi.org/10.4103/jcrt.JCRT_212_19