Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review.

Authors :: Al Rajaibi R
Al Rumhi T
Al Abri AM
Source :: Sultan Qaboos University medical journal [Sultan Qaboos Univ Med J] 2021 Aug; Vol. 21 (3), pp. 491-494. Date of Electronic Publication: 2021 Aug 29.
Publication Year :: 2021
Abstract: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening mucocutaneous drug reactions. Several therapies have been used in the treatment of SJS/TEN but none of them have yet been established as the gold standard treatment. Studies have shown that cyclosporine (CsA) can be used off-label in TEN/SJS, which has shown promising therapeutic effectiveness in such diseases. Here we report a 38-year-old woman who presented to Ar Rustaq Hospital, Rustaq, Oman in 2019 with SJS/TEN overlap and was treated successfully with CsA along with supportive management. This case report also includes a literature review on the use of CsA in the treatment of SJS/TEN.<br /> (© Copyright 2021, Sultan Qaboos University Medical Journal, All Rights Reserved.)

Subjects :: Adult
Carbamazepine adverse effects
Cyclosporine therapeutic use
Female
Humans
Oman
Stevens-Johnson Syndrome diagnosis
Stevens-Johnson Syndrome drug therapy
Stevens-Johnson Syndrome etiology

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