Pathophysiology of COVID-19: Everywhere You Look You Will See ACE 2 !

Authors :: Cousin VL
Giraud R
Bendjelid K
Source :: Frontiers in medicine [Front Med (Lausanne)] 2021 Aug 27; Vol. 8, pp. 694029. Date of Electronic Publication: 2021 Aug 27 (Print Publication: 2021).
Publication Year :: 2021
Abstract: Angiotensin converting enzyme 2 (ACE <subscript>2</subscript> ) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE <subscript>2</subscript> . Second, the relative deficiency of ACE <subscript>2</subscript> during infection could be linked to several clinical features encountered during the disease, like ARDS and coagulation abnormalities. This study explores the strong link between ACE <subscript>2</subscript> and the majority of risk factors for the severe evolution of COVID-19. It seems that all these risks factors are linked to an increased level of ACE <subscript>2</subscript> and/or imbalance in ACE/ACE <subscript>2</subscript> .<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Cousin, Giraud and Bendjelid.)