Drugs in Focus: Octreotide Use in Children With Gastrointestinal Disorders.

Authors :: Mas E
Borrelli O
Broekaert I
de-Carpi JM
Dolinsek J
Miele E
Pienar C
Koninckx CR
Thomassen RA
Thomson M
Tzivinikos C
Benninga MA
Source :: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2022 Jan 01; Vol. 74 (1), pp. 1-6.
Publication Year :: 2022
Abstract: Abstract: Octreotide, a somatostatin analogue, has been used for more than 20 years in children with gastrointestinal bleeding, chylothorax or chylous ascites, intestinal lymphangiectasia, pancreatitis, intestinal dysmotility, and severe diarrhoea; however, until now, there is a lack of randomised clinical trials evaluating the efficacy of this compound in childhood. Hence, we aimed to review the literature in order to determine the evidence of its use and safety in children, using PubMed from 2000 to 2021 with the search terms "octreotide" and "children" and "bleeding or chylous ascites or chylothorax or acute pancreatitis or lymphangiectasia or diarrhoea or intestinal dysmotility".<br />Competing Interests: The authors report no conflicts of interest.<br /> (Copyright © 2021 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)