Back to Search
Start Over
MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 31; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 31. - Publication Year :
- 2021
-
Abstract
- Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.
- Subjects :
- Biomarkers analysis
Brain Ischemia complications
Brain Ischemia genetics
Cerebral Infarction complications
Cerebral Infarction genetics
Humans
Intracranial Aneurysm complications
Intracranial Aneurysm genetics
MicroRNAs metabolism
Prognosis
Vasospasm, Intracranial genetics
MicroRNAs genetics
Subarachnoid Hemorrhage complications
Subarachnoid Hemorrhage genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34502401
- Full Text :
- https://doi.org/10.3390/ijms22179492