Back to Search
Start Over
Application of plasma polymerized pyrrole nanoparticles to prevent or reduce de-differentiation of adult rat ventricular cardiomyocytes.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2021 Sep 09; Vol. 32 (9), pp. 121. Date of Electronic Publication: 2021 Sep 09. - Publication Year :
- 2021
-
Abstract
- Cardiovascular diseases are the leading cause of death in the world, cell therapies have been shown to recover cardiac function in animal models. Biomaterials used as scaffolds can solve some of the problems that cell therapies currently have, plasma polymerized pyrrole (PPPy) is a biomaterial that has been shown to promote cell adhesion and survival. The present research aimed to study PPPy nanoparticles (PPPyN) interaction with adult rat ventricular cardiomyocytes (ARVC), to explore whether PPPyN could be employed as a nanoscaffold and develop cardiac microtissues. PPPyN with a mean diameter of 330 nm were obtained, the infrared spectrum showed that some pyrrole rings are fragmented and that some fragments of the ring can be dehydrogenated during plasma synthesis, it also showed the presence of amino groups in the structure of PPPyN. PPPyN had a significant impact on the ARVC´s shape, delaying dedifferentiation, necrosis, and apoptosis processes, moreover, the cardiomyocytes formed cell aggregates up to 1.12 mm <superscript>2</superscript> with some aligned cardiomyocytes and generated fibers on its surface similar to cardiac extracellular matrix. PPPyN served as a scaffold for adult ARVC. Our results indicate that PPPyN-scaffold is a biomaterial that could have potential application in cardiac cell therapy (CCT).<br /> (© 2021. The Author(s).)
- Subjects :
- Animals
Cell Dedifferentiation drug effects
Cells, Cultured
Down-Regulation drug effects
Extracellular Matrix chemistry
Extracellular Matrix drug effects
Heart Ventricles cytology
Heart Ventricles drug effects
Male
Materials Testing
Myocytes, Cardiac physiology
Plasma Gases pharmacology
Polymerization drug effects
Pyrroles chemistry
Rats
Rats, Wistar
Myocytes, Cardiac drug effects
Nanoparticles chemistry
Pyrroles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34499229
- Full Text :
- https://doi.org/10.1007/s10856-021-06595-7