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Progress and challenges in understanding the regulation and function of p53 dynamics.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2021 Nov 01; Vol. 49 (5), pp. 2123-2131. - Publication Year :
- 2021
-
Abstract
- The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses. Here, we review recent advances in our understanding of the molecular mechanisms regulating p53 dynamics and the functions of the dynamics in the regulation of p53-dependent cell stress responses. We also compare dynamic encoding in the p53 system with that found in other important cell signaling systems, many of which can interact with the p53 network. Finally, we highlight some of the current challenges in understanding dynamic cell signaling within a larger cellular network context.<br /> (© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
- Subjects :
- Animals
Cell Cycle Checkpoints genetics
Cell Proliferation genetics
DNA Damage genetics
DNA Repair genetics
Gene Expression
Gene Expression Regulation
Humans
Kinetics
Transcription Factors genetics
Transcription Factors metabolism
Signal Transduction genetics
Tumor Suppressor Protein p53 genetics
Tumor Suppressor Protein p53 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 49
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 34495325
- Full Text :
- https://doi.org/10.1042/BST20210148