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AA amyloidosis complicating monoclonal gammopathies, an unusual feature validating the concept of "monoclonal gammopathy of inflammatory significance"?
- Source :
-
International journal of clinical practice [Int J Clin Pract] 2021 Nov; Vol. 75 (11), pp. e14817. Date of Electronic Publication: 2021 Sep 21. - Publication Year :
- 2021
-
Abstract
- Introduction: AL amyloidosis is caused by the proliferation of an immunoglobulin-secreting B cell clone. AA amyloidosis is a rare complication of chronic inflammation. However, some patients present with diseases combining monoclonal immunoglobulin production and chronic inflammation. The aim of this work was to describe cases of AA amyloidosis associated with monoclonal gammopathies.<br />Patients and Methods: We reviewed all patients reported in French national amyloid centres presenting with AA amyloidosis and monoclonal gammopathy and performed a literature review. The quality of AA amyloidosis diagnosis and the causal relationship with monoclonal gammopathy were assessed.<br />Results: In total, four patients from our centres and eight from the literature fulfilled the inclusion criteria. The haematological disorders presenting with monoclonal gammopathy were as follows: Waldenström macroglobulinaemia (n = 8), Schnitzler syndrome (n = 2), multiple myeloma (n = 1) and monoclonal gammopathy of undetermined significance (n = 1). Treatment strategies varied among the cases, with the treatment of the haematological disorder in 4 and anti-inflammatory treatment in 2.<br />Conclusion: Monoclonal gammopathies might be a rare and poorly known cause of AA amyloidosis. Such monoclonal gammopathies could be named "monoclonal gammopathies of inflammatory significance."<br /> (© 2021 John Wiley & Sons Ltd.)
- Subjects :
- Humans
Amyloidosis complications
Immunoglobulin Light-chain Amyloidosis complications
Monoclonal Gammopathy of Undetermined Significance complications
Monoclonal Gammopathy of Undetermined Significance diagnosis
Multiple Myeloma
Paraproteinemias complications
Waldenstrom Macroglobulinemia
Subjects
Details
- Language :
- English
- ISSN :
- 1742-1241
- Volume :
- 75
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 34490695
- Full Text :
- https://doi.org/10.1111/ijcp.14817