Back to Search Start Over

Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation.

Authors :
Shupe LE
Miles FP
Jones G
Yun R
Mishler J
Rembado I
Murphy RL
Perlmutter SI
Fetz EE
Source :
Frontiers in neuroscience [Front Neurosci] 2021 Aug 19; Vol. 15, pp. 718465. Date of Electronic Publication: 2021 Aug 19 (Print Publication: 2021).
Publication Year :
2021

Abstract

Toward addressing many neuroprosthetic applications, the Neurochip3 (NC3) is a multichannel bidirectional brain-computer interface that operates autonomously and can support closed-loop activity-dependent stimulation. It consists of four circuit boards populated with off-the-shelf components and is sufficiently compact to be carried on the head of a non-human primate (NHP). NC3 has six main components: (1) an analog front-end with an Intan biophysical signal amplifier (16 differential or 32 single-ended channels) and a 3-axis accelerometer, (2) a digital control system comprised of a Cyclone V FPGA and Atmel SAM4 MCU, (3) a micro SD Card for 128 GB or more storage, (4) a 6-channel differential stimulator with ±60 V compliance, (5) a rechargeable battery pack supporting autonomous operation for up to 24 h and, (6) infrared transceiver and serial ports for communication. The NC3 and earlier versions have been successfully deployed in many closed-loop operations to induce synaptic plasticity and bridge lost biological connections, as well as deliver activity-dependent intracranial reinforcement. These paradigms to strengthen or replace impaired connections have many applications in neuroprosthetics and neurorehabilitation.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Shupe, Miles, Jones, Yun, Mishler, Rembado, Murphy, Perlmutter and Fetz.)

Details

Language :
English
ISSN :
1662-4548
Volume :
15
Database :
MEDLINE
Journal :
Frontiers in neuroscience
Publication Type :
Academic Journal
Accession number :
34489634
Full Text :
https://doi.org/10.3389/fnins.2021.718465