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A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?
- Source :
-
BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2021 Oct; Vol. 43 (10), pp. e2100005. Date of Electronic Publication: 2021 Sep 05. - Publication Year :
- 2021
-
Abstract
- Dandruff is a common scalp condition, which frequently causes psychological distress in those affected. Dandruff is considered to be caused by an interplay of several factors. However, the pathogenesis of dandruff remains under-investigated, especially with respect to the contribution of the hair follicle. As the hair follicle exhibits unique immune-modulatory properties, including the creation of an immunoinhibitory, immune-privileged milieu, we propose a novel hypothesis taking into account the role of the hair follicle. We hypothesize that the changes and imbalance of yeast and bacterial species, along with increasing proinflammatory sebum by-products, leads to the activation of immune response and inflammation. Hair follicle keratinocytes may then detect these changes in scalp microbiota resulting in the recruitment of leukocytes to the inflammation site. These changes in the scalp skin immune-microenvironment may impact hair follicle immune privilege status, which opens new avenues into exploring the role of the hair follicle in dandruff pathogenesis. Also see the video abstract here: https://youtu.be/mEZEznCYtNs.<br /> (© 2021 The Authors. BioEssays published by Wiley Periodicals LLC.)
- Subjects :
- Hair Follicle
Humans
Inflammation
Scalp
Dandruff
Dermatitis, Seborrheic
Subjects
Details
- Language :
- English
- ISSN :
- 1521-1878
- Volume :
- 43
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- BioEssays : news and reviews in molecular, cellular and developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 34486144
- Full Text :
- https://doi.org/10.1002/bies.202100005