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The effects of periodontitis associated microbiota on the development of oral squamous cell carcinoma.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Oct 22; Vol. 576, pp. 80-85. Date of Electronic Publication: 2021 Aug 05. - Publication Year :
- 2021
-
Abstract
- Epidemiological data have shown that periodontal bacterial infection, periodontitis, and oral squamous cell carcinoma have close relationship on the disease progress and risk. However, the specific role of periodontal microbes and their mechanism in the development of oral squamous cell carcinoma is not yet clear. In our previous work, metagenomic Illumina Mi-seq analysis was used to identify tstructure and abundance of periodontital microbiome. Accoding to the results, we used Porphyromonas.spp. and Fusobacterium.spp. as the periodontitis positive microbiota; Neisseria.spp and Corynebacterium.spp as periodontitis negative microbiota (their average relative abundance were >5%). These representative strains of the above genus were used to infect OSCC cells to explore their effect on tumor cell biology behavior, and detect the expression level of the gene in related to inflammation, migration, invasion and cell cycle. We find that periodontitis positive correlated microbiota had a promoting effect on the development of oral squamous cell carcinoma in vitro by regulating mRNA and protein expression of IL-6, IL-8, MMP-9 and Cyclin-D1. Periodontitis negative correlated microbiota had suppression effect on the development of oral squamous cell carcinoma in vitro analysis.<br />Competing Interests: Declaration of competing interest No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Bacteroidaceae Infections complications
Bacteroidaceae Infections microbiology
Bacteroidaceae Infections pathology
Cell Line, Tumor
Cell Movement physiology
Corynebacterium genetics
Corynebacterium isolation & purification
Fusobacterium Infections complications
Fusobacterium Infections microbiology
Fusobacterium Infections pathology
Fusobacterium nucleatum genetics
Fusobacterium nucleatum isolation & purification
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms pathology
Humans
Neisseria sicca genetics
Neisseria sicca isolation & purification
Neisseriaceae Infections complications
Neisseriaceae Infections microbiology
Neisseriaceae Infections pathology
Porphyromonas gingivalis genetics
Porphyromonas gingivalis isolation & purification
Squamous Cell Carcinoma of Head and Neck metabolism
Squamous Cell Carcinoma of Head and Neck pathology
Head and Neck Neoplasms microbiology
Microbiota
Periodontitis microbiology
Squamous Cell Carcinoma of Head and Neck microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 576
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 34482027
- Full Text :
- https://doi.org/10.1016/j.bbrc.2021.07.092