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Stress-Related Amygdala Metabolic Activity Is Associated With Low Bone Mineral Density in Postmenopausal Women: A Pilot 18 F-FDG PET/CT Study.
- Source :
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Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Aug 12; Vol. 12, pp. 719265. Date of Electronic Publication: 2021 Aug 12 (Print Publication: 2021). - Publication Year :
- 2021
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Abstract
- Background: Psychological stress is associated with postmenopausal osteoporosis. However, the underlying mechanism of stress-related brain neural activity with osteoporosis is not fully elucidated. <superscript>18</superscript> F-fluorodeoxyglucose positron emission tomography/computed tomography ( <superscript>18</superscript> F-FDG PET/CT) is an established method to evaluate the metabolic activity of brain amygdala, a region involved in stress. We aimed to evaluate the relationship between metabolic activity of amygdala (AmygA) and osteoporosis in postmenopausal women.<br />Materials and Methods: A total of 115 postmenopausal women who underwent <superscript>18</superscript> F-FDG PET/CT and dual-energy X-ray absorptiometry for routine health screening were enrolled in this study. AmygA was defined as the maximum standardized uptake value (SUVmax) of amygdala divided by the mean SUV of temporal lobe. The levels of psychological stress were measured using the Psychosocial Well-being Index-Short Form (PWI-SF).<br />Results: The participants with osteoporosis exhibited significantly higher AmygA than without osteoporosis (0.81 ± 0.16 vs . 0.61 ± 0.13, p < 0.001). The AmygA value of 0.69 was suggested as an optimal cut-off value to identify participant with osteoporosis (sensitivity; 79.1%, specificity; 83.3%, area under the curve; 0.841, p < 0.001). Furthermore, AmygA showed significant association with osteoporosis in postmenopausal woman by multivariate analysis. Psychological stress scale (PWI-SF) was well correlated with AmygA and AmygA was highest in high stress risk-, intermediate in moderate stress risk-, and lowest in healthy group.<br />Conclusions: AmygA measured by <superscript>18</superscript> F-FDG PET/CT is associated with osteoporosis in postmenopausal women. Our results provide the possibility that stress-related neurobiological activity involving amygdala is linked with postmenopausal osteoporosis.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Pahk, Kwon, Joung and Kim.)
- Subjects :
- Aged
Amygdala diagnostic imaging
Bone Diseases, Metabolic diagnosis
Bone Diseases, Metabolic etiology
Bone Diseases, Metabolic metabolism
Bone Diseases, Metabolic psychology
Female
Humans
Middle Aged
Osteoporosis, Postmenopausal diagnostic imaging
Osteoporosis, Postmenopausal metabolism
Osteoporosis, Postmenopausal psychology
Pilot Projects
Positron Emission Tomography Computed Tomography
Postmenopause metabolism
Postmenopause psychology
Republic of Korea
Amygdala metabolism
Fluorodeoxyglucose F18 pharmacokinetics
Osteoporosis, Postmenopausal etiology
Stress, Psychological complications
Stress, Psychological diagnostic imaging
Stress, Psychological metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1664-2392
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 34475851
- Full Text :
- https://doi.org/10.3389/fendo.2021.719265