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Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Colon Cancer in Elderly Patients: A Propensity Score Analysis.
- Source :
-
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4471-4478. - Publication Year :
- 2021
-
Abstract
- Aim: This study aimed to evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in elderly patients with Stage I-III colon cancer for long-term oncologic outcomes.<br />Patients and Methods: We retrospectively reviewed 175 patients aged >75 years who underwent radical surgery for Stage I-III colon cancer between 2000 and 2015 at our institute. Overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) were evaluated according to NLR values using propensity score analysis. Patients were allocated to the higher NLR (H-NLR) or the lower NLR (L-NLR) group with a cut-off value of 2.3, based on receiver operating characteristic curve.<br />Results: Before case matching, there were significant differences between the two groups for CSS (p=0.023) and RFS (p<0.001), but not for OS (p=0.069). Similar results were obtained after case matching, with significant differences observed for CSS (p=0.003) and RFS (p=0.027), but not for OS (p=0.145).<br />Conclusion: NLR may be a prognostic factor in elderly patients with colon cancer.<br /> (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Colonic Neoplasms pathology
Digestive System Surgical Procedures
Disease-Free Survival
Female
Humans
Lymphocyte Count
Male
Neoplasm Staging
Prognosis
ROC Curve
Retrospective Studies
Treatment Outcome
Colonic Neoplasms blood
Colonic Neoplasms surgery
Neutrophils metabolism
Propensity Score
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 41
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 34475071
- Full Text :
- https://doi.org/10.21873/anticanres.15256