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Rh III -Catalyzed Direct Heteroarylation of C(sp 3 )-H and C(sp 2 )-H Bonds in Heterocycles with N -Heteroaromatic Boronates.
- Source :
-
Organic letters [Org Lett] 2021 Sep 17; Vol. 23 (18), pp. 7177-7182. Date of Electronic Publication: 2021 Sep 02. - Publication Year :
- 2021
-
Abstract
- Herein, we disclose a Rh <superscript>III</superscript> -catalyzed heteroarylation of C(sp <superscript>3</superscript> )-H and C(sp <superscript>2</superscript> )-H bonds in heterocycles with organoboron reagents. This protocol displays high efficiency and excellent functional group tolerance. A range of heterocyclic boronates with strong coordinating atoms, including pyridine, pyrimidine, pyrazole, thiophene, and furan derivatives, can be extensively served as the coupling reagents. The direct heteroarylation method could supply potential application in terms of the synthesis of drug molecules with multiple heterocycles.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 23
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 34472870
- Full Text :
- https://doi.org/10.1021/acs.orglett.1c02546