An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia.

Authors :: Watanabe R
Kawakami I
Ikeuchi T
Murayama S
Arai T
Akiyama H
Onaya M
Hasegawa M
Source :: ENeurologicalSci [eNeurologicalSci] 2021 Jul 28; Vol. 24, pp. 100363. Date of Electronic Publication: 2021 Jul 28 (Print Publication: 2021).
Publication Year :: 2021
Abstract: •We report the immunohistochemical and biochemical features of an FTDP-17 case with MAPT IVS 10 + 14C > T mutation.•Postmortem examination of the patient with bvFTD revealed diffuse neuronal and glial 4-repeat tau pathology similar to CBD.•The structure of tau filaments associated with MAPT IVS 10 + 14C > T mutation was characterized by electron microscopy.<br />Competing Interests: None.<br /> (© 2021 The Authors. Published by Elsevier B.V.)

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