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Memantine and its benefits for cancer, cardiovascular and neurological disorders.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2021 Nov 05; Vol. 910, pp. 174455. Date of Electronic Publication: 2021 Aug 27. - Publication Year :
- 2021
-
Abstract
- Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that was initially indicated for the treatment of moderate to severe Alzheimer's disease. It is now also considered for a variety of other pathologies in which activation of NMDA receptors apparently contributes to the pathogenesis and progression of disease. In addition to the central nervous system (CNS), NMDA receptors can be found in non-neuronal cells and tissues that recently have become an interesting research focus. Some studies have shown that glutamate signaling plays a role in cell transformation and cancer progression. In addition, these receptors may play a role in cardiovascular disorders. In this review, we focus on the most recent findings for memantine with respect to its pharmacological effects in a range of diseases, including inflammatory disorders, cardiovascular diseases, cancer, neuropathy, as well as retinopathy.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cardiovascular Diseases metabolism
Excitatory Amino Acid Antagonists pharmacokinetics
Excitatory Amino Acid Antagonists therapeutic use
Humans
Inflammation drug therapy
Inflammation metabolism
Memantine pharmacokinetics
Memantine therapeutic use
Neoplasms metabolism
Nervous System Diseases metabolism
Oxidative Stress drug effects
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate metabolism
Retinal Diseases drug therapy
Retinal Diseases metabolism
Cardiovascular Diseases drug therapy
Excitatory Amino Acid Antagonists pharmacology
Memantine pharmacology
Neoplasms drug therapy
Nervous System Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 910
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34461125
- Full Text :
- https://doi.org/10.1016/j.ejphar.2021.174455