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2D Black Phosphorus-Based Cytomembrane Mimics with Stimuli-Responsive Antibacterial Action Inspired by Endotoxin-Associated Toxic Behavior.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Sep 15; Vol. 13 (36), pp. 43820-43829. Date of Electronic Publication: 2021 Aug 30. - Publication Year :
- 2021
-
Abstract
- Biomimetic membrane materials have been widely explored and developed for drug loading and tissue engineering applications due to their excellent biocompatibility and abundant reaction sites. However, novel cytomembrane mimics have been lacking for a long time. In this study, black phosphorus (BP) was used as the foundation for a new generation of promising cytomembrane mimics due to its multiple similarities to cytomembranes. Inspired by the dual function of endotoxins on membranes, we prepared a BP-based cytomembrane mimic with controllable antibacterial ability via electrostatic interaction between BP and [1-pentyl-1-quaternary ammonium-3-vinyl-imidazole]Br ([PQVI]Br). The release of PQVI could be manipulated in different conditions by adjusting the electrostatic force, thereby achieving controllable antibacterial ability. This report confirms the possibility of using BP as a new material to mimic cytomembranes and provides a new concept of controllable antibacterial action based on endotoxins.
- Subjects :
- Anti-Bacterial Agents chemistry
Drug Liberation
Escherichia coli drug effects
Imidazoles chemistry
Microbial Sensitivity Tests
Quaternary Ammonium Compounds chemistry
Anti-Bacterial Agents pharmacology
Delayed-Action Preparations chemistry
Imidazoles pharmacology
Membranes, Artificial
Phosphorus chemistry
Quaternary Ammonium Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 13
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34460222
- Full Text :
- https://doi.org/10.1021/acsami.1c15220