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Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 12; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 12. - Publication Year :
- 2021
-
Abstract
- Prostate cancer (PCa) is the leading cause of cancer-associated mortality in men, and new biomarkers are still needed. The expression pattern and protein tissue localization of proteoglycans of the syndecan family (SDC 1-4) and syntenin-1 (SDCBP) were determined in normal and prostatic tumor tissue from two genetically engineered mouse models and human prostate tumors. Studies were validated using SDC 1-4 and SDCBP mRNA levels and patient survival data from The Cancer Genome Atlas and CamCAP databases. RNAseq showed increased expression of Sdc1 in Pb-Cre4/Pten <superscript>f/f</superscript> mouse Pca and upregulation of Sdc3 expression and downregulation of Sdc2 and Sdc4 when compared to the normal prostatic tissue in Pb-Cre4/Trp53 <superscript>f/f</superscript> -;Rb1 <superscript>f/f</superscript> mouse tumors. These changes were confirmed by immunohistochemistry. In human PCa, SDC 1-4 and SDCBP immunostaining showed variable localization. Furthermore, Kaplan-Meier analysis showed that patients expressing SDC3 had shorter prostate-specific survival than those without SDC3 expression (log-rank test, p = 0.0047). Analysis of the MSKCC-derived expression showed that SDC1 and SDC3 overexpression is predictive of decreased biochemical recurrence-free survival ( p = 0.0099 and p = 0.045, respectively), and SDC4 overexpression is predictive of increased biochemical recurrence-free survival ( p = 0.035). SDC4 overexpression was associated with a better prognosis, while SDC1 and SDC3 were associated with more aggressive tumors and a worse prognosis.
- Subjects :
- Aged
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Transplantation
Prognosis
Prostatic Neoplasms genetics
Prostatic Neoplasms metabolism
Protein Array Analysis
Sequence Analysis, RNA
Survival Analysis
Syndecan-1 metabolism
Syndecan-3 metabolism
Syndecan-4 metabolism
Syntenins genetics
Syntenins metabolism
Gene Expression Profiling methods
Prostatic Neoplasms pathology
Syndecan-1 genetics
Syndecan-3 genetics
Syndecan-4 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34445387
- Full Text :
- https://doi.org/10.3390/ijms22168669