Back to Search
Start Over
Bifidobacterium animalis subsp. lactis BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome.
- Source :
-
Nutrients [Nutrients] 2021 Aug 17; Vol. 13 (8). Date of Electronic Publication: 2021 Aug 17. - Publication Year :
- 2021
-
Abstract
- The administration of broad-spectrum antibiotics is often associated with antibiotic-associated diarrhea (AAD), and impacts gastrointestinal tract homeostasis, as evidenced by the following: (a) an overall reduction in both the numbers and diversity of the gut microbiota, and (b) decreased short-chain fatty acid (SCFA) production. Evidence in humans that probiotics may enhance the recovery of microbiota populations after antibiotic treatment is equivocal, and few studies have addressed if probiotics improve the recovery of microbial metabolic function. Our aim was to determine if Bifidobacterium animalis subsp. lactis BB-12 (BB-12)-containing yogurt could protect against antibiotic-induced fecal SCFA and microbiota composition disruptions. We conducted a randomized, allocation-concealed, controlled trial of amoxicillin/clavulanate administration (days 1-7), in conjunction with either BB-12-containing or control yogurt (days 1-14). We measured the fecal levels of SCFAs and bacterial composition at baseline and days 7, 14, 21, and 30. Forty-two participants were randomly assigned to the BB-12 group, and 20 participants to the control group. Antibiotic treatment suppressed the fecal acetate levels in both the control and probiotic groups. Following the cessation of antibiotics, the fecal acetate levels in the probiotic group increased over the remainder of the study and returned to the baseline levels on day 30 (-1.6% baseline), whereas, in the control group, the acetate levels remained suppressed. Further, antibiotic treatment reduced the Shannon diversity of the gut microbiota, for all the study participants at day 7. The magnitude of this change was larger and more sustained in the control group compared to the probiotic group, which is consistent with the hypothesis that BB-12 enhanced microbiota recovery. There were no significant baseline clinical differences between the two groups. Concurrent administration of amoxicillin/clavulanate and BB-12 yogurt, to healthy subjects, was associated with a significantly smaller decrease in the fecal SCFA levels and a more stable taxonomic profile of the microbiota over time than the control group.
- Subjects :
- Adolescent
Adult
Aged
Colon
Diarrhea etiology
Diarrhea microbiology
Diarrhea prevention & control
Gastrointestinal Tract metabolism
Humans
Middle Aged
Yogurt microbiology
Young Adult
Anti-Bacterial Agents adverse effects
Bifidobacterium animalis metabolism
Fatty Acids, Volatile metabolism
Feces chemistry
Feces microbiology
Gastrointestinal Microbiome
Gastrointestinal Tract microbiology
Probiotics therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 13
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 34444974
- Full Text :
- https://doi.org/10.3390/nu13082814