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Systemic Administration of PTH Supports Vascularization in Segmental Bone Defects Filled with Ceramic-Based Bone Graft Substitute.
- Source :
-
Cells [Cells] 2021 Aug 11; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 11. - Publication Year :
- 2021
-
Abstract
- Non-unions continue to present a challenge to trauma surgeons, as current treatment options are limited, duration of treatment is long, and the outcome often unsatisfactory. Additionally, standard treatment with autologous bone grafts is associated with comorbidity at the donor site. Therefore, alternatives to autologous bone grafts and further therapeutic strategies to improve on the outcome and reduce cost for care providers are desirable. In this study in Sprague-Dawley rats we employed a recently established sequential defect model, which provides a platform to test new potential therapeutic strategies on non-unions while gaining mechanistic insight into their actions. The effects of a combinatorial treatment of a bone graft substitute (HACaS+G) implantation and systemic PTH administration was assessed by µ-CT, histological analysis, and bio-mechanical testing and compared to monotreatment and controls. Although neither PTH alone nor the combination of a bone graft substitute and PTH led to the formation of a stable union, our data demonstrate a clear osteoinductive and osteoconductive effect of the bone graft substitute. Additionally, PTH administration was shown to induce vascularization, both as a single adjuvant treatment and in combination with the bone graft substitute. Thus, systemic PTH administration is a potential synergistic co-treatment to bone graft substitutes.
- Subjects :
- Animals
Antigens, CD metabolism
Antigens, Differentiation, Myelomonocytic metabolism
Bone Regeneration drug effects
Bone Remodeling drug effects
Bone Substitutes pharmacology
Bone Transplantation
Calcium Sulfate administration & dosage
Calcium Sulfate pharmacology
Combined Modality Therapy
Drug Combinations
Durapatite administration & dosage
Durapatite pharmacology
Femoral Fractures therapy
Gentamicins administration & dosage
Gentamicins pharmacology
Lipopolysaccharide Receptors metabolism
Rats
Rats, Sprague-Dawley
Bone Substitutes administration & dosage
Fractures, Ununited therapy
Neovascularization, Physiologic drug effects
Parathyroid Hormone administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 10
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 34440827
- Full Text :
- https://doi.org/10.3390/cells10082058