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Inborn errors of immunity manifesting as atopic disorders.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Nov; Vol. 148 (5), pp. 1130-1139. Date of Electronic Publication: 2021 Aug 21. - Publication Year :
- 2021
-
Abstract
- Inborn errors of immunity are traditionally best known for enhancing susceptibility to infections. However, allergic inflammation, among other types of immune dysregulation, occurs frequently in patients with inborn errors of immunity. As such, the term primary atopic disorders (PADs) was recently coined to describe the group of heritable monogenic allergic disorders. It is becoming increasingly important for clinicians to recognize that allergic diseases such as food allergy, atopic dermatitis, and allergic asthma are expressions of misdirected immunity, and in patients who present with severe, early-onset, or coexisting allergic conditions, these can be indications of an underlying PAD. Identifying monogenic allergic disease through next-generation sequencing can dramatically improve outcomes by allowing the use of precision-based therapy targeting the patient's underlying molecular defect. It is therefore imperative that clinicians recognize PADs to be able to provide informed therapeutic options and improve patient outcomes. Here, we summarize the clinical features commonly seen with each of the currently known PADs, identify clinical warning signs that warrant assessment for PADs, and lastly, discuss the benefits of timely diagnosis and management of these conditions.<br /> (Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Disease Management
Disease Susceptibility
Genetic Association Studies
Humans
Hypersensitivity, Immediate diagnosis
Hypersensitivity, Immediate therapy
Phenotype
Genetic Predisposition to Disease
Hypersensitivity, Immediate epidemiology
Hypersensitivity, Immediate etiology
Immunity genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 148
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34428518
- Full Text :
- https://doi.org/10.1016/j.jaci.2021.08.008