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Clock proteins and training modify exercise capacity in a daytime-dependent manner.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Aug 31; Vol. 118 (35). - Publication Year :
- 2021
-
Abstract
- Exercise and circadian biology are closely intertwined with physiology and metabolism, yet the functional interaction between circadian clocks and exercise capacity is only partially characterized. Here, we tested different clock mutant mouse models to examine the effect of the circadian clock and clock proteins, namely PERIODs and BMAL1, on exercise capacity. We found that daytime variance in endurance exercise capacity is circadian clock controlled. Unlike wild-type mice, which outperform in the late compared with the early part of their active phase, PERIODs- and BMAL1-null mice do not show daytime variance in exercise capacity. It appears that BMAL1 impairs and PERIODs enhance exercise capacity in a daytime-dependent manner. An analysis of liver and muscle glycogen stores as well as muscle lipid utilization suggested that these daytime effects mostly relate to liver glycogen levels and correspond to the animals' feeding behavior. Furthermore, given that exercise capacity responds to training, we tested the effect of training at different times of the day and found that training in the late compared with the early part of the active phase improves exercise performance. Overall, our findings suggest that clock proteins shape exercise capacity in a daytime-dependent manner through changes in liver glycogen levels, likely due to their effect on animals' feeding behavior.<br />Competing Interests: The authors declare no competing interest.
- Subjects :
- ARNTL Transcription Factors physiology
Animals
CLOCK Proteins genetics
Feeding Behavior
Female
Light
Liver Glycogen metabolism
Male
Mice
Mice, Inbred C57BL
Muscles metabolism
Mutation
Period Circadian Proteins physiology
Photoperiod
Sex Characteristics
Time Factors
CLOCK Proteins physiology
Exercise Tolerance physiology
Physical Conditioning, Animal physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 118
- Issue :
- 35
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 34426495
- Full Text :
- https://doi.org/10.1073/pnas.2101115118