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Radiation exposure of the operators in the preparation and administration of yttrium-90 microspheres in the treatment of malignant hepatic lesions: What is the risk?
- Source :
-
Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol (Engl Ed)] 2021 Sep-Oct; Vol. 40 (5), pp. 293-298. - Publication Year :
- 2021
-
Abstract
- Liver radioembolization is an emerging treatment against liver primary and secondary tumours. The whole procedure of radioembolization involves different health care specialists with different expertise. During the fractionation and infusion phases, the personnel manipulates high activities of <superscript>90</superscript> Y. In our centre, the number of radioembolization treatments per year is increasing; the aim of this study is to monitor the dose to the operators and to estimate the radiological risk for the operators involved in the RE. At present, two medical devices are approved: Sir-Sphere® and Therasphere™, both loaded with <superscript>90</superscript> Y. The dosimeters used were TLDs placed over the fingertips, for a total of 4 dosimeters for each phase; the selected dose descriptor was Hp <subscript>0.07</subscript> . The study concerned 17 patients affected by malignant hepatic lesions, treated from September 2017 to March 2018. We performed 27 procedures: 10 fractionations (with Sir-Sphere®) and 17 infusions to the patients (10 with Sir-Spheres®, 7 with Theraspheres™). For fractionation phase, the average activity of each preparation was 3.34 GBq, the average value of Hp <subscript>0.07</subscript> was 0.50mSv. For infusion phase, the average activity was 1.51 GBq for Sir-Sphere® and 2.10 GBq for Theraspheres™, the average value of Hp <subscript>0.07</subscript> was 0.10mSv. No significant differences were found between senior (Hp <subscript>0.07</subscript> = 0.08mSv) and young operators (Hp <subscript>0.07</subscript> = 0.09mSv), respectively. Similarly, no significant differences were found between the right and left hand, with the same average value of Hp <subscript>0.07</subscript> (0.01mSv). In conclusion, the results are encouraging, since fingertips reported doses very low. The handling of <superscript>90</superscript> Y microspheres and the radioembolization procedure can be carried out under safe conditions.<br /> (Copyright © 2020 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Female
Fingers radiation effects
Hand radiation effects
Humans
Male
Microspheres
Middle Aged
Radiation Dosage
Radiation Dosimeters
Radiation Protection methods
Time Factors
Carcinoma, Hepatocellular radiotherapy
Embolization, Therapeutic instrumentation
Embolization, Therapeutic methods
Embolization, Therapeutic statistics & numerical data
Liver Neoplasms radiotherapy
Occupational Exposure
Radiation Exposure
Yttrium Radioisotopes administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2253-8089
- Volume :
- 40
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revista espanola de medicina nuclear e imagen molecular
- Publication Type :
- Academic Journal
- Accession number :
- 34425970
- Full Text :
- https://doi.org/10.1016/j.remnie.2020.05.005