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Triple-Jump Photodynamic Theranostics: MnO 2 Combined Upconversion Nanoplatforms Involving a Type-I Photosensitizer with Aggregation-Induced Emission Characteristics for Potent Cancer Treatment.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2021 Oct; Vol. 33 (41), pp. e2103748. Date of Electronic Publication: 2021 Aug 22. - Publication Year :
- 2021
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Abstract
- The development of multifunctional nanoplatforms has been recognized as a promising strategy for potent photodynamic theranostics. Aggregation-induced emission (AIE) photosensitizers undergoing Type-I reactive oxygen species (ROS) generation pathway appear as potential candidates due to their capability of hypoxia-tolerance, efficient ROS production, and fluorescence imaging navigation. To further improve their performance, a facile and universal method of constructing a type of glutathione (GSH)-depleting and near-infrared (NIR)-regulated nanoplatform for dual-modal imaging-guided photodynamic therapy (PDT) is presented. The nanoplatforms are obtained through the coprecipitation process involving upconversion nanoparticles (UCNPs) and AIE-active photosensitizers, followed by in situ generation of MnO <subscript>2</subscript> as the outer shell. The introduction of UCNPs actualizes the NIR-activation of AIE-active photosensitizers to produce ·OH as a Type-I ROS. Intracellular upregulated GSH-responsive decomposition of the MnO <subscript>2</subscript> shell to Mn <superscript>2+</superscript> realizes GSH-depletion, which is a distinctive approach for elevating intracellular ·OH. Meanwhile, the generated Mn <superscript>2+</superscript> can implement T <subscript>1</subscript> -weighted magnetic resonance imaging (MRI) in specific tumor sites, and mediate the conversion of intracellular H <subscript>2</subscript> O <subscript>2</subscript> to ·OH. These outputs reveal a triple-jump ·OH production, and this approach brings about distinguished performance in FLI-MRI-guided PDT with high-efficacy, which presents great potential for future clinical translations.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Animals
Cell Line, Tumor
Cell Survival drug effects
Glutathione chemistry
Glutathione metabolism
Hydrogen Peroxide chemistry
Hydrogen Peroxide metabolism
Infrared Rays
Magnetic Resonance Imaging
Magnetite Nanoparticles therapeutic use
Magnetite Nanoparticles toxicity
Mice
Mice, Nude
Neoplasms drug therapy
Photochemotherapy methods
Photosensitizing Agents therapeutic use
Reactive Oxygen Species metabolism
Transplantation, Homologous
Magnetite Nanoparticles chemistry
Manganese Compounds chemistry
Oxides chemistry
Photosensitizing Agents chemistry
Theranostic Nanomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 33
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 34423484
- Full Text :
- https://doi.org/10.1002/adma.202103748