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mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.
- Source :
-
Nature immunology [Nat Immunol] 2021 Oct; Vol. 22 (10), pp. 1306-1315. Date of Electronic Publication: 2021 Aug 20. - Publication Year :
- 2021
-
Abstract
- B.1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization. We demonstrate how the dose and number of immunizations influence protection. Nonhuman primates received two doses of 30 or 100 µg of Moderna's mRNA-1273 vaccine, a single immunization of 30 µg, or no vaccine. Two doses of 100 µg of mRNA-1273 induced 50% inhibitory reciprocal serum dilution neutralizing antibody titers against live SARS-CoV-2 p.Asp614Gly and B.1.351 of 3,300 and 240, respectively. Higher neutralizing responses against B.1.617.2 were also observed after two doses compared to a single dose. After challenge with B.1.351, there was ~4- to 5-log <subscript>10</subscript> reduction of viral subgenomic RNA and low to undetectable replication in bronchoalveolar lavages in the two-dose vaccine groups, with a 1-log <subscript>10</subscript> reduction in nasal swabs in the 100-µg group. These data establish that a two-dose regimen of mRNA-1273 will be critical for providing upper and lower airway protection against major variants of concern.<br /> (© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.)
- Subjects :
- 2019-nCoV Vaccine mRNA-1273
Animals
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
COVID-19 virology
Cell Line
Chlorocebus aethiops
Female
Humans
Macaca mulatta
Male
Mesocricetus
Primates virology
RNA, Viral immunology
Spike Glycoprotein, Coronavirus immunology
Vaccination methods
Vero Cells
Viral Load methods
COVID-19 immunology
COVID-19 Vaccines immunology
Primates immunology
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 22
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34417590
- Full Text :
- https://doi.org/10.1038/s41590-021-01021-0