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Hypolipidemic and reduced nitrergic effects of p-hydroxycinnamic diesters extracted from Copernicia prunifera in mice challenged by a high-fat diet.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Oct; Vol. 142, pp. 111930. Date of Electronic Publication: 2021 Aug 17. - Publication Year :
- 2021
-
Abstract
- Dyslipidemia is a chronic non-transmissible condition that has increased due to an unhealthy lifestyle. Statins have been used as the standard treatment to control hyperlipidemia. However, side effects and high costs may be associated with its prolonged treatment, so plants derivatives have been an attractive therapy to overcome these problems. Among the compounds extracted from plants, the p-hydroxycinnamic diesters (HCE), present in carnauba wax (CW), have been found with good pharmacological properties. Therefore, this study aimed to evaluate the potential anti-hypercholesterolemic and possible toxicological effects of HCE in C57BL/6J mice under a high-fat (HF) diet. Male C57BL/6J mice were fed during 60 days under the HF diet and therefore were either treated with HCE (200 and 400 mg/kg) or simvastatin (20 mg/kg) or received saline (controls) by gavage for 30 days under the same diet. HCE treatment was able to reduce serum total cholesterol and LDL levels. Besides, this compound increased liver X receptor (LXR) and but not significantly affected IL-1β and TNF-α liver mRNA transcription activity. In conclusion, HCE treatment was found safe and may attenuate the deleterious effects of dyslipidemia due to chronic feeding with western diets.<br /> (Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Biomarkers metabolism
Body Weight drug effects
Coumaric Acids administration & dosage
Coumaric Acids isolation & purification
Coumaric Acids toxicity
Diet, High-Fat adverse effects
Disease Models, Animal
Female
Hyperlipidemias blood
Hyperlipidemias chemically induced
Hypolipidemic Agents administration & dosage
Hypolipidemic Agents toxicity
Inflammation genetics
Interleukin-1beta metabolism
Lipid Metabolism genetics
Lipids blood
Liver drug effects
Liver metabolism
Liver X Receptors metabolism
Male
Mice, Inbred C57BL
Plant Extracts administration & dosage
Plant Extracts toxicity
Simvastatin administration & dosage
Simvastatin pharmacology
Mice
Arecaceae chemistry
Coumaric Acids pharmacology
Hyperlipidemias drug therapy
Hypolipidemic Agents pharmacology
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 142
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 34416631
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.111930