Cytotoxicity of isoflavones from Millettia dura .

Authors :: Buyinza D
Yang LJ
Derese S
Ndakala A
Coghi P
Heydenreich M
Wong VKW
Möller HM
Yenesew A
Source :: Natural product research [Nat Prod Res] 2021 Aug; Vol. 35 (16), pp. 2744-2747. Date of Electronic Publication: 2019 Sep 06.
Publication Year :: 2021
Abstract: The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC <subscript>50</subscript> values of 6-14 μM. Durmillone was the most active with IC <subscript>50</subscript> values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC <subscript>50</subscript> = 58.4 μM), LO2 hepatocytes (IC <subscript>50</subscript> 78.7 μM) and CCD19Lu fibroblasts (IC <subscript>50</subscript> >100 μM).