Inflamm-Aging-Related Cytokines of IL-17 and IFN- γ Accelerate Osteoclastogenesis and Periodontal Destruction.

Periodontal disease (PD), as an age-related disease, prevalent in middle-aged and elderly population, is characterized as inflammatory periodontal tissue loss, including gingival inflammation and alveolar bone resorption. However, the definite mechanism of aging-related inflammation in PD pathology needs further investigation. Our study is aimed at exploring the effect of inflamm-aging-related cytokines of interleukin-17 (IL-17) and interferon- γ (IFN- γ ) on osteoclastogenesis in vitro and periodontal destruction in vivo . For receptor activator of nuclear factor- κ B ligand- (RANKL-) primed bone marrow macrophages (BMMs), IL-17 and IFN- γ enhanced osteoclastogenesis, with the expression of osteoclastogenic mRNA (TRAP, c-Fos, MMP-9, Ctsk, and NFATc1) and protein (c-Fos and MMP-9) upregulated. Ligament-induced rat models were established to investigate the role of IL-17 and IFN- γ on experimental periodontitis. Both IL-17 and IFN- γ could enhance the local inflammation in gingival tissues. Although there might be an antagonistic interaction between IL-17 and IFN- γ , IL-17 and IFN- γ could facilitate alveolar bone loss and osteoclast differentiation.
Competing Interests: All authors declare that there are no conflicts of interest associated with this study.
(Copyright © 2021 Jingyi Tan et al.)