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Acanthoscurria gomesiana spider-derived synthetic mygalin in the dorsal raphe nucleus modulates acute and chronic pain.
- Source :
-
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Oct; Vol. 35 (10), pp. e22877. Date of Electronic Publication: 2021 Aug 12. - Publication Year :
- 2021
-
Abstract
- Mygalin, a diacylspermidine that is naturally found in the hemolymph of the spider Acanthoscurria gomesiana, is of interest for development as a potential analgesic. Previous studies have shown that acylpolyamines modulate glutamatergic receptors with the potential to alter pain pathways. This study aimed to evaluate the effects of mygalin on acute and chronic pain in rodents. For evaluation of acute pain, Wistar rats were subjected to tail-flick and hot-plate nociceptive tests. For the evaluation of chronic neuropathic pain, a partial ligation of the sciatic nerve was performed and, 21 days later, animals were examined in hot-plate, tail-flick, acetone, and von Frey tests. Either Mygalin or vehicle was microinjected in the dorsal raphe nucleus (DRN) before the tests. Another group was pretreated with selective antagonists of glutamate receptors (LY 235959, MK-801, CNQX, and NBQX). Mygalin decreases nociceptive thresholds on both acute and chronic neuropathic pain models in all the tests performed. The lowest dose of mygalin yielded the most effective nociception, showing an increase of 63% of the nociceptive threshold of animals with neuropathic chronic pain. In conclusion, mygalin microinjection in the DRN results in antinociceptive effect in models of neuropathic pain, suggesting that acylpolyamines and their derivatives, such as this diacylspermidine, could be pursued for the treatment of neuropathic pain and development of selective analgesics.<br /> (© 2021 Wiley Periodicals LLC.)
- Subjects :
- Animals
Disease Models, Animal
Hemolymph chemistry
Male
Microinjections methods
Rats
Rats, Wistar
Spermidine administration & dosage
Treatment Outcome
Acute Pain drug therapy
Analgesics administration & dosage
Chronic Pain drug therapy
Dorsal Raphe Nucleus drug effects
Neuralgia drug therapy
Spermidine analogs & derivatives
Spiders metabolism
Synthetic Drugs administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0461
- Volume :
- 35
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of biochemical and molecular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 34382705
- Full Text :
- https://doi.org/10.1002/jbt.22877