Validation of memory assessment in the Starmaze task: Data from 14 month-old APPPS1 mice and controls.

This article describes navigation data of 14 month-old APPPS1 and C57Bl6 in the Starmaze task. These data were acquired as positive controls of memory deficit in a model of the familial form of Alzheimers's disease (see Schmitt et al., Flexibility as a marker of early cognitive decline in humanized Apolipoprotein E ε4 (ApoE4) mice, Neurobiol Aging, 2021). They were acquired in a reduced version of the Starmaze environment and accompanied by a number of acquisitions in different control groups at 6 and 14 months to assess the robustness of the procedure and its associated memory scores. These data illustrate the extraction of a variety of navigation scores (including search strategy, spatial learning and memory) and provide a reference of navigation data in the Starmaze task for healthy 6-month-old controls, normal aging and a model of pathological memory deficit.
Competing Interests: JS, PB and LA were full-time employees of Sanofi when this study was performed. The CNRS, LRR and her lab have financial interest in the sale of the Starmaze task. This work was supported by Sanofi (PB, JS, LA), the CNRS and Sorbonne University through UMR 8246 (LRR). The group of LRR is a member of the Labex BioPsy and ENP Foundation. This work also received support under the program Investissements d'Avenir launched by the French Government and implemented by the ANR, with the references ANR-10-LABX-BioPsy (LRR). Labex are supported by French State funds managed by the ANR within the Investissements d'Avenir program under reference ANR-11-IDEX-0004–02.
(© 2021 The Author(s). Published by Elsevier Inc.)