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Nanomedicine based approaches for combating viral infections.

Authors :
Shah S
Chougule MB
Kotha AK
Kashikar R
Godugu C
Raghuvanshi RS
Singh SB
Srivastava S
Source :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Oct 10; Vol. 338, pp. 80-104. Date of Electronic Publication: 2021 Aug 08.
Publication Year :
2021

Abstract

Millions of people die each year from viral infections across the globe. There is an urgent need to overcome the existing gap and pitfalls of the current antiviral therapy which include increased dose and dosing frequency, bioavailability challenges, non-specificity, incidences of resistance and so on. These stumbling blocks could be effectively managed by the advent of nanomedicine. Current review emphasizes over an enhanced understanding of how different lipid, polymer and elemental based nanoformulations could be potentially and precisely used to bridle the said drawbacks in antiviral therapy. The dawn of nanotechnology meeting vaccine delivery, role of RNAi therapeutics in antiviral treatment regimen, various regulatory concerns towards clinical translation of nanomedicine along with current trends and implications including unexplored research avenues for advancing the current drug delivery have been discussed in detail.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1873-4995
Volume :
338
Database :
MEDLINE
Journal :
Journal of controlled release : official journal of the Controlled Release Society
Publication Type :
Academic Journal
Accession number :
34375690
Full Text :
https://doi.org/10.1016/j.jconrel.2021.08.011