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A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer.
- Source :
-
Nutrients [Nutrients] 2021 Jul 15; Vol. 13 (7). Date of Electronic Publication: 2021 Jul 15. - Publication Year :
- 2021
-
Abstract
- A high-fat diet (HFD) and obesity are risk factors for many diseases including breast cancer. This is particularly important with close to 40% of the current adult population being overweight or obese. Previous studies have implicated that Mediterranean diets (MDs) partially protect against breast cancer. However, to date, the links between diet and breast cancer progression are not well defined. Therefore, to begin to define and assess this, we used an isocaloric control diet (CD) and two HFDs enriched with either olive oil (OOBD, high in oleate, and unsaturated fatty acid in MDs) or a milk fat-based diet (MFBD, high in palmitate and myristate, saturated fatty acids in Western diets) in a mammary polyomavirus middle T antigen mouse model (MMTV-PyMT) of breast cancer. Our data demonstrate that neither MFBD or OOBD altered the growth of primary tumors in the MMTV-PyMT mice. The examination of lung metastases revealed that OOBD mice exhibited fewer surface nodules and smaller metastases when compared to MFBD and CD mice. These data suggest that different fatty acids found in different sources of HFDs may alter breast cancer metastasis.
- Subjects :
- Animal Feed
Animals
Antigens, Polyomavirus Transforming
Breast Neoplasms genetics
Breast Neoplasms metabolism
Female
Lung Neoplasms genetics
Lung Neoplasms metabolism
Mammary Tumor Virus, Mouse genetics
Olive Oil toxicity
Risk Assessment
Risk Factors
Tumor Burden
Tumor Necrosis Factor-alpha metabolism
Breast Neoplasms pathology
Diet, High-Fat adverse effects
Dietary Fats toxicity
Fatty Acids toxicity
Lung Neoplasms secondary
Milk toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 34371939
- Full Text :
- https://doi.org/10.3390/nu13072431