Evidence from a meta-analysis for association of MC4R rs17782313 and FTO rs9939609 polymorphisms with susceptibility to obesity in children.

Authors :: Dastgheib SA
Bahrami R
Setayesh S
Salari S
Mirjalili SR
Noorishadkam M
Sadeghizadeh-Yazdi J
Akbarian E
Neamatzadeh H
Source :: Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2021 Sep-Oct; Vol. 15 (5), pp. 102234. Date of Electronic Publication: 2021 Jul 30.
Publication Year :: 2021
Abstract: Background and Aim: The aim of this study was to evaluate the association of MC4R rs17782313 and FTO rs9939609 polymorphisms with childhood obesity. Methods: A universal search was performed up to May 2021. Results: A total of 31 studies including 13 studies with 9565 cases and 11956 controls on MC4R rs17782313 and 18 studies with 4789 cases and 15918 controls on FTO rs9939609 were selected. Conclusions: Pooled data showed that FTO rs9930506 and MC4R rs17782313 polymorphisms were significantly associated with obesity in children. Stratified analyses revealed that these genetic variants were associated with childhood obesity in Caucasian and Asian children. Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest. (Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.)

Subjects :: Child
Humans
Pediatric Obesity etiology
Pediatric Obesity metabolism
Prognosis
Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics
Genetic Predisposition to Disease
Pediatric Obesity pathology
Polymorphism, Single Nucleotide
Receptor, Melanocortin, Type 4 genetics

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