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Short- and long-term effects of fluticasone furoate/vilanterol in exercising asthmatic adolescents: A randomized and open label trial.
- Source :
-
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Nov; Vol. 129 (5), pp. 369-375. Date of Electronic Publication: 2021 Aug 25. - Publication Year :
- 2021
-
Abstract
- Purpose: Relvar® (fluticasone furoate [FF]/vilanterol [VI]) is a once-daily inhaler with bronchodilator effect lasting 24 h. Our aim was to investigate the short- and long-term effects of FF/VI on exercise-induced asthma (EIA) in adolescents.<br />Methods: Ninety-three adolescent asthmatics aged 12-18 years were referred for evaluation of EIA. Following a positive exercise challenge test (ECT), 22/44 were allocated to a single administration of salbutamol (400 μg) and 22/44 to FF/VI (92/22 μg) in a double-blind method. Thirty-five subjects were reassessed by repeat ECT 30-60 days of FF/VI.<br />Results: Median FEV <subscript>1</subscript> change post-ECT at baseline was -22.8% predicted (interquartile range [IQR] -26.1 and -18.0) for salbutamol and -21.0 (IQR -30.7 and -16.8) for FF/VI. Following bronchodilator, FEV <subscript>1</subscript> improved similarly in both groups. Repeat ECT following 30-60 days of FF/VI resulted in negative ECT in 33/35 subjects; the median decrease in FEV <subscript>1</subscript> of these 35 subjects was 22.6% predicted (IQR 29-18) before, and 4.6% predicted (IQR 8.7-2.5) after 30-60 days of FF/VI treatment (p < 0.0001).<br />Conclusions: FF/VI is effective in reversing EIA after 15 min in adolescents and in protecting EIA after 30-60 days in adolescents. Larger studies are needed to assess the effect of FF/VI on EIA.<br /> (© 2021 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.)
- Subjects :
- Administration, Inhalation
Adolescent
Albuterol pharmacology
Androstadienes pharmacology
Asthma physiopathology
Benzyl Alcohols pharmacology
Bronchodilator Agents pharmacology
Child
Chlorobenzenes pharmacology
Double-Blind Method
Drug Combinations
Exercise Test
Female
Forced Expiratory Volume drug effects
Humans
Male
Nebulizers and Vaporizers
Prospective Studies
Time Factors
Treatment Outcome
Albuterol administration & dosage
Androstadienes administration & dosage
Asthma drug therapy
Benzyl Alcohols administration & dosage
Bronchodilator Agents administration & dosage
Chlorobenzenes administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1742-7843
- Volume :
- 129
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Basic & clinical pharmacology & toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 34359097
- Full Text :
- https://doi.org/10.1111/bcpt.13640