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Dietary flaxseed reduces Myocardial Ischemic Lesions, improves cardiac function and lowers cholesterol levels despite the presence of severe obesity in JCR:LA-cp Rats.
- Source :
-
The Journal of nutritional biochemistry [J Nutr Biochem] 2021 Dec; Vol. 98, pp. 108829. Date of Electronic Publication: 2021 Aug 03. - Publication Year :
- 2021
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Abstract
- Previous work has shown that dietary flaxseed can significantly reduce cardiac damage from a coronary artery ligation-induced myocardial infarction. However, this model uses healthy animals and the ligation creates the infarct in an artificial manner. The purpose of this study was to determine if dietary flaxseed can protect the hearts of JCR:LA-cp rats, a model of genetic obesity and metabolic syndrome, from naturally occurring myocardial ischemic lesions. Male and female obese rats were randomized into four groups (n = 8 each) to receive, for 12 weeks, either a) control diet (Con), b) control diet supplemented with 10% ground flaxseed (CFlax), c) a high-fat, high sucrose (HFHS) diet, or d) HFHS supplemented with 10% ground flaxseed (HFlax). Male and female JCR:LA-cp lean rats served as genetic controls and received similar dietary interventions. In male obese rats, serum total cholesterol and LDL-C were significantly lower in CFlax compared to Con.  Obese rats on HFHS exhibited increased myocardial ischemic lesions and diastolic dysfunction regardless of sex. HFlax significantly lowered the frequency of cardiac lesions and improved diastolic function in male and female obese rats compared to HFHS. Blood pressures were similar in obese and lean rats. No aortic atherosclerotic lesions were detectable in any group. Collectively, this study shows that a HFHS diet increased myocardial ischemic lesion frequency and abolished the protective effect of female sex on cardiac function. More importantly, the data demonstrates dietary flaxseed protected against the development of small spontaneous cardiac infarcts despite the ingestion of a HFHS diet and the presence of morbid obesity.<br />Competing Interests: Declaration of competing interests The authors declare that there are no conflicts of interest.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Atherosclerosis prevention & control
Blood Pressure
Cardiovascular Diseases prevention & control
Diet, High-Fat adverse effects
Dietary Sucrose adverse effects
Dietary Supplements
Female
Heart physiopathology
Male
Metabolic Syndrome diet therapy
Myocardium pathology
Rats
Sex Factors
Cholesterol blood
Flax
Myocardial Ischemia prevention & control
Obesity, Morbid diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4847
- Volume :
- 98
- Database :
- MEDLINE
- Journal :
- The Journal of nutritional biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34358644
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2021.108829