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Morphological changes in amblyopic eyes in choriocapillaris and Sattler's layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through quantification of mean reflectivity: A pilot study.
- Source :
-
PloS one [PLoS One] 2021 Aug 06; Vol. 16 (8), pp. e0255735. Date of Electronic Publication: 2021 Aug 06 (Print Publication: 2021). - Publication Year :
- 2021
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Abstract
- Purpose: Establishing the reliability of a new method to check the mean retinal and choroidal reflectivity and using it to find retinal and choroid changes in amblyopia.<br />Methods: Design: Retrospective case-control. Population: 28 subjects of which 10 were healthy controls (20 eyes): 8 with refractive errors, 1 with strabismus, and 1 with both. 18 patients with unilateral amblyopia included: 7 anisometropic, 6 isoametropic, 1 strabismic, and 4 combined. Mean participants' age: 13.77 years ± 10.28. Observation procedures: SD-OCT and ImageJ. Main outcome measure: mean reflectivity of retinal and choroid layers. Amblyopic, fellow, and healthy eyes were compared.<br />Results: The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler's layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). The RNFL reflectivity was lower than that of fellow eyes (p = 0.025). Post-hoc pairwise comparisons showed statistically significant differences between amblyopic and healthy eyes for choriocapillaris (p = 0.018) and Sattler's (p = 0.035), and between amblyopic and fellow eyes for RNFL (p = 0.039).<br />Conclusion: A decrease in reflectivity of the choriocapillaris and Sattler's in amblyopic compared to healthy eyes, and a decrease in reflectivity of the RNFL in the amblyopic compared to fellow eyes, indicate that the pathophysiology is partly peripheral and might be bilateral.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adolescent
Adult
Amblyopia pathology
Anisometropia diagnostic imaging
Child
Child, Preschool
Choroid diagnostic imaging
Choroid physiology
Choroid ultrastructure
Eye ultrastructure
Female
Humans
Male
Middle Aged
Nerve Fibers pathology
Nerve Fibers ultrastructure
Pilot Projects
Retina pathology
Retina ultrastructure
Retinal Ganglion Cells pathology
Strabismus diagnostic imaging
Strabismus pathology
Tomography, Optical Coherence
Visual Acuity physiology
Young Adult
Amblyopia diagnostic imaging
Anisometropia pathology
Eye diagnostic imaging
Retina diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 34358257
- Full Text :
- https://doi.org/10.1371/journal.pone.0255735