Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients.

This letter reports an unexpected increase of the ACE2 product angiotensin-(1-7) and a parallel decrease of its substrate angiotensin II, suggesting a dysregulation of the renin-angiotensin system towards angiotensin-(1-7) formation in #COVID19 patients https://bit.ly/3xFXuTU.
Competing Interests: Conflict of interest: A.L. Valle Martins reports a patent pending (BR1020210009950). Conflict of interest: F.A. da Silva has nothing to disclose. Conflict of interest: L. Bolais-Ramos has nothing to disclose. Conflict of interest: G.C. de Oliveira has nothing to disclose. Conflict of interest: R.C. Ribeiro has nothing to disclose. Conflict of interest: D.A.A. Pereira has nothing to disclose. Conflict of interest: F. Annoni has nothing to disclose. Conflict of interest: M.M.L. Diniz has nothing to disclose. Conflict of interest: T.G.F. Silva has nothing to disclose. Conflict of interest: B. Ziviani has nothing to disclose. Conflict of interest: A.C. Cardoso has nothing to disclose. Conflict of interest: J.C. Martins has nothing to disclose. Conflict of interest: D. Motta-Santos has nothing to disclose. Conflict of interest: M.J. Campagnole-Santos has nothing to disclose. Conflict of interest: F.S. Taccone has nothing to disclose. Conflict of interest: T. Verano-Braga has nothing to disclose. Conflict of interest: R.A.S. Santos reports patents planned.
(Copyright ©The authors 2021.)