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Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice.
- Source :
-
Frontiers in pharmacology [Front Pharmacol] 2021 Jul 19; Vol. 12, pp. 712442. Date of Electronic Publication: 2021 Jul 19 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia. The relationship between the sensory nervous system and modulation of the renin-angiotensin system has been described, focusing on pain and neurodegeneration in several animal models. We assessed the effect of the RAS modulator, ramipril, an angiotensin converting-enzyme inhibitor in a mouse model of OXP-induced acute pain syndrome. OXP was administered in Swiss mice at a cumulative dose of 15 mg/kg (3 x 5 mg/kg/3 days, i.p.). RAM was administered i.p. every day from 24 h before the first OXP injection until the end of the experiments. We evaluated OIAS development and treatment effects by sensorimotor tests, intraepidermal nerve fiber and dorsal root ganglia-neuron immunohistochemical analyses, and sciatic nerve ultrastructural analysis. OXP-treated mice showed tactile allodynia and cold hypersensitivity, without motor impairment and evidence of nerve degeneration. RAM prevented cold sensitivity and improved recovery of normal tactile sensitivity in OXP-treated mice. Our finding that RAM alleviates OXP-induced pain is a step towards evaluating its therapeutic potential in patients receiving OXP treatment.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Bouchenaki, Danigo, Bernard, Bessaguet, Richard, Sturtz, Balayssac, Magy and Demiot.)
Details
- Language :
- English
- ISSN :
- 1663-9812
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34349658
- Full Text :
- https://doi.org/10.3389/fphar.2021.712442