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Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction.
- Source :
-
The Journal of laryngology and otology [J Laryngol Otol] 2021 Oct; Vol. 135 (10), pp. 879-882. Date of Electronic Publication: 2021 Aug 05. - Publication Year :
- 2021
-
Abstract
- Background: Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity.<br />Method: Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared.<br />Results: There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction.<br />Conclusion: This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.
- Subjects :
- Adult
Bone Resorption etiology
Bone Resorption metabolism
Bone Resorption pathology
Case-Control Studies
Cholesteatoma, Middle Ear metabolism
Cholesteatoma, Middle Ear pathology
Chronic Disease
Female
Humans
Male
Middle Aged
Osteoclasts pathology
Otitis Media diagnosis
Otitis Media metabolism
Tartrate-Resistant Acid Phosphatase blood
Cholesteatoma, Middle Ear complications
Osteoclasts enzymology
Otitis Media complications
Subjects
Details
- Language :
- English
- ISSN :
- 1748-5460
- Volume :
- 135
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of laryngology and otology
- Publication Type :
- Academic Journal
- Accession number :
- 34348812
- Full Text :
- https://doi.org/10.1017/S0022215121002103